Matthew J. Hamilton, MD

matthew-j-hamilton-mdPhysician, Gastroenterology, Hepatology and Endoscopy

Dr. Matthew Hamilton, a leading member of the research team at the BWH Crohn’s and Colitis Center, has garnered national recognition for his research into the underlying inflammatory processes of IBD. He takes a rigorous scientific approach to understanding each patient’s disease while also working with patients as active participants in their own care.

At the Center, Dr. Hamilton’s is investigating how environmental influences, such as the use of antibiotics, may alter the bacterial populations inside the intestines and the connections between those changes and the development of IBD.

Dr. Hamilton also performs fecal transplants for recurrent Clostridium difficile infections and is investigating how aspects of this procedure might be an effective treatment for certain types of IBD.

His research of inflammation is focused on the mast cells of the immune system and the role they may play in IBD. Mast cells are probably most familiar for releasing histamine and other substances that produce the mucus secretion and other symptoms associated with an allergic reaction. Dr. Hamilton has helped identify a subset of patients with mast cell activation syndrome (MCAS), and the National Institutes of Health and the Crohn’s and Colitis Foundation of America are funding his mast cell research. His central hypothesis is that activated mast cells stuck in the “on” position release substances that fuel intestinal inflammation to cause IBD.

In addition to his research and clinical work with patients, Dr. Hamilton teaches medical students, residents, and research fellows. He is active in the IBD community as a speaker and volunteer for fund-raising activities.

Dr. Hamilton is a graduate of Haverford College in Haverford, PA, and the University of Maryland School of Medicine in Baltimore. He was trained in internal medicine as an intern and resident at Boston Medical Center and was a gastroenterology research fellow at Brigham and Women’s Hospital and Harvard Medical School.